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Baclofen and tizanidine are the only two drugs FDA approved for muscle spasticity. Generally, cyclobenzaprine is more effective in treating acute musculoskeletal pain due to an injury in the back or neck. In head-to-head studies with Baclofen for those conditions, tizanidine tends to have fewer side effects — but they both work just as well. For instance cyclobenzaprine may be more appropriate in somebody with muscle issues and some type of neuropathy. Both medications start with small doses and increase over time. Baclofen often starts at 5 mg, three times per day, and should not exceed 80 mg per day. This is not a first-line choice for acute neck or back muscle pain, though. But it is observed that in some scenarios, Baclofen is more effective and considered better than Tizanidine, while in other circumstances, Tizanidine is better than Baclofen Tizanidine is slightly stronger than baclofen, though they aren’t extremely different in their appropriate doses. Chronic pain from muscle spasticity related to neurological disease or injury responds best to baclofen.. Prescribed for more Prescription only. Tizanidine treatment often starts at 2 mg three to four times per day and should not exceed 36 mg per day At the end of the trial, neurologists and physiotherapists thought that baclofen was superior on the basis of perceived efficacy and tolerance (p less than or equal to 0. Level 1 Spasticity is where the muscles undergo continuous contraction, which leads to tightness and stiffness. These medicines are similar in many ways and work for a similar cause. Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity 6) Baclofen Similar to tizanidine, Baclofen is primarily used for spasticity in spinal cord injury patients or those with multiple sclerosis. Baclofen and Tizanidine help to relieve pain caused due to muscle spasms and other injuries. Comparing Baclofen vs Tizanidine Baclofen Tizanidine Prescription only Baclofen relieves muscle spasms associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk. A standard starting dose of baclofen is five milligrams, three times per day. You shouldn’t exceed 80 milligrams in a day According to appropriate safe dose recommendations, tizanidine is stronger and needs smaller doses than baclofen to be effective. Drowsiness occurs in up to 20% of folks taking it, and there are better options for neck and back muscle pain. 5 / 5 average rating with 33 reviews forbaclofen. Often times the selection will depend on the mechanism of action/Side effect profile in the underlying ailment.