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After the oral dose the elimination had a half-life of 3. Minimum therapeutic plasma levels of CARDIZEM. As the dose of CARDIZEM CD capsules is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area-under-the-curve of 2. Administration biphasic elimination was observed, with a distribution half-life of 0. A departure from linearity similar to that seen with CARDIZEM tablets and CARDIZEM SR capsules is observed The apparent elimination half-life after single or multiple dosing is 5 to 8 hours. As the dose of Cardizem tablets is increased from a daily dose of 120 mg (30 mg qid) to 240 mg (60 mg qid) daily, there is an increase in area-under-the-curve of 2. A departure from linearity similar to that seen with CARDIZEM tablets and CARDIZEM SR capsules is observed. 7 times elimination half-life following single or multiple drug administration is approximately 3. 7 times The apparent elimination half-life after single or multiple dosing is 5 to 8 hours. Fall queen 30 June 2010 Single oral doses of 30 to 120 mg of Cardizem tablets result in detectable plasma levels within 30 to 60 minutes and peak plasma levels 2 to 4 hours after drug administration. 3 times When Cardizem CD was coadministered with a high fat content breakfast, the extent of diltiazem absorption was not affected. Continuous Infusion: Dilution: Dilute 125 mg in 100 mL, 250 mg in 250 mL, or 250 mg in 500 mL of 0. 71/kg and the total clearance was 1. The apparent elimination half-life after single or multiple dosing is 5 to 8 hours. Desacetyl diltiazem is also present in the plasma at levels of 10% to 20% of the parent drug and is 25% to 50% as potent as a coronary vasodilator as diltiazem. A departure from linearity similar to that seen with CARDIZEM tablets and CARDIZEM SR capsules is observed Immediate-release formulations: 30 to 120 mg/dose administered 3 to 4 times daily; usual daily dosage range: 180 to 360 mg/day. Extended-release formulations: Capsule, extended release (once daily dosing; eg, Cardizem CD, Tiazac): 120 to 300 mg once daily When CARDIZEM CD was coadministered with a high fat content breakfast, the extent of diltiazem absorption was not affected. 0 h; the apparent volume of distribution was 5. 2 h and an elimination half-life of 3. More simply put, the half-life of a drug is how long it takes for half of it to be eliminated from the bloodstream. A medication's half-life is the time it takes for the plasma concentration of a drug to reach half of its original concentration. Infusion is stable for 24 hr at room temperature or if refrigerated After i. As the dose of CARDIZEM CD capsules is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area under the curve of 2. IV Push: Dilution: Administer bolus dose undiluted.

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